Generic Name : Sitagliptin + Metformin HCL
Brand Name : Istamet 50/1000 mg
Manufacturer Name : Sun Pharma
Product Code : OBP 1201
Delivery Days : 10 To 12 Working Days
Composition : Sitagliptin + Metformin hcl
Strength : 50+1000mg
Packaging : Tablets (Blister)
Presentation : Pills Strip
Drug Class : Dipeptidyl peptidase-4 (DPP-4) inhibitors + Biguanides
Prescribed For : Control high blood sugar levels in people with type 2 diabetes mellitus
Side Effects : Hypoglycemia (low blood glucose level), Nausea, Diarrhea, Bronchitis (inflammation of the airways), Anemia (low number of red blood cells)
Istamet 50/1000 MG is a pharmaceutical medication used in the treatment of type 2 diabetes. This combination drug contains two active ingredients: Sitagliptin (50 MG) and Metformin (1000 MG).
Istamet 50/1000 MG Tablet works through a combination of its two active ingredients, Sitagliptin (50 MG) and Metformin (1000 MG), to effectively manage blood sugar levels in individuals with type 2 diabetes. Let's explore how each of these components contributes to its mode of action:
Sitagliptin (50 MG):
Sitagliptin is a Dipeptidyl Peptidase-4 (DPP-4) inhibitor. It functions by inhibiting the DPP-4 enzyme, which is responsible for breaking down incretin hormones in the body. Incretin hormones are essential for regulating blood sugar levels. They work by stimulating the release of insulin from the pancreas and inhibiting the release of glucagon, another hormone that raises blood sugar levels. When DPP-4 is inhibited by Sitagliptin, it prolongs the action of incretin hormones. This leads to two key effects:
Increased Insulin Release: By extending the activity of incretin hormones, Sitagliptin promotes a more significant release of insulin. Insulin is crucial for helping cells in the body take up and utilize glucose, which in turn lowers blood sugar levels.
Reduced Glucagon Production: The extended action of incretin hormones also suppresses the release of glucagon, a hormone that normally raises blood sugar levels. This results in further blood sugar control.
Metformin (1000 MG):
Metformin is a biguanide, and its mode of action complements that of Sitagliptin. Metformin primarily works in the following ways:
Decreased Liver Glucose Production: Metformin reduces the amount of glucose produced by the liver. The liver is known to release glucose into the bloodstream, especially when blood sugar levels are low. Metformin helps to lower this excessive glucose output.
Improved Insulin Sensitivity: Metformin enhances the sensitivity of muscle cells to insulin. This means that the cells are more responsive to the effects of insulin, allowing them to take up and utilize glucose more efficiently.
Istamet 50/1000 MG Tablets are a combination medication, and they contain the following active ingredients:
Sitagliptin (50 MG): This is a Dipeptidyl Peptidase-4 (DPP-4) inhibitor. Sitagliptin is responsible for increasing the levels of incretin hormones in the body by inhibiting the DPP-4 enzyme. By doing so, it enhances insulin release and reduces glucagon production, both of which help in controlling blood sugar levels.
Metformin (1000 MG): Metformin is classified as a biguanide. It works by decreasing the amount of glucose produced by the liver and improving the sensitivity of muscle cells to insulin. This dual mechanism helps in reducing blood sugar levels and improving the body's utilization of insulin.
The dosage of Istamet 50/1000 MG Tablets can vary depending on the individual's specific medical condition and the instructions provided by a healthcare professional. Typically, it is taken orally as directed by a doctor, often with meals to minimize stomach discomfort. Dosages may be adjusted to achieve optimal blood sugar control.
Here are some general guidelines on who can use Istamet 50/1000 MG:
When using Istamet 50/1000 MG Tablets to manage type 2 diabetes, it's essential to be aware of common mistakes and to avoid them. Here are some mistakes to steer clear of:
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Q: What is Istamet 50/1000 MG used for?
A: Istamet 50/1000 MG is primarily used for the management and control of blood sugar levels in individuals with type 2 diabetes.
Q: How does Istamet 50/1000 MG work?
A: Istamet 50/1000 MG contains two active ingredients, Sitagliptin and Metformin, which work in combination to increase insulin release, decrease glucagon production, reduce liver glucose production, and improve insulin sensitivity for better blood sugar control.
Q: What is the recommended dosage for Istamet 50/1000 MG?
A: The recommended dosage varies depending on your individual health condition and the guidance of your healthcare provider. Always follow your doctor's prescription.
Q: Should Istamet 50/1000 MG be taken with or without food?
A: Istamet 50/1000 MG can be taken with or without food. Taking it with meals can help reduce the likelihood of stomach discomfort.
Q: What should I do if I miss a dose of Istamet 50/1000 MG?
A: If you miss a dose, take it as soon as you remember. If it's close to the time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule.
Q: Are there any common side effects of Istamet 50/1000 MG?
A: Common side effects may include nausea, vomiting, diarrhea, abdominal discomfort, headache, and the possibility of hypoglycemia. If you experience unusual or severe side effects, contact your healthcare provider.
Q: Can Istamet 50/1000 MG cause hypoglycemia (low blood sugar)?
A: Yes, Istamet 50/1000 MG can lead to low blood sugar (hypoglycemia). It's important to monitor your blood sugar levels regularly and be aware of the symptoms of hypoglycemia.
Q: Is it safe to buy Istamet 50/1000 MG online?
A: Purchasing medications online should be done with caution. It's essential to use reputable and licensed online pharmacies and consult with a healthcare provider for guidance.
Q: Can Istamet 50/1000 MG be used during pregnancy and breastfeeding?
A: If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using Istamet 50/1000 MG, as it may not be suitable for these circumstances.
Q: Should I make any dietary or lifestyle changes while taking Istamet 50/1000 MG?
A: Yes, Istamet 50/1000 MG is most effective when combined with a healthy diet and lifestyle modifications. Work with your healthcare provider to make appropriate changes to support your diabetes management.
Common side effects of Istamet 50/1000 MG may include:
Istamet 50/1000 MG Tablets are primarily prescribed to individuals with type 2 diabetes for the following uses:
Here are some general instructions on how to use Istamet 50/1000 MG Tablets:
The information provided on website is intended for educational purposes only and should not be used as a substitute for professional medical advice. Please consult a qualified healthcare professional for personalized medical advice.
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