Generic Name : Sitagliptin
Brand Name : Januvia
Manufacturer Name : Merck
Product Code : OBP 323
Delivery Days : 10 To 12 Working Days
Composition : Sitagliptin
Strength : 100mg
Packaging : Tablet (Blisters)
Presentation : Pills Strip
Drug Class : Dipeptidyl peptidase-4 (DPP-4) inhibitors
Prescribed For : Lowers blood sugar levels in adult patients with type 2 diabetes mellitus
Side Effects : Upper respiratory infection, stuffy or runny nose and sore throat, and headache
| Pack Size/Qty | Price | Price Per Pill or unit | |
| 84 TABLET'S | $144.48 | $1.72 | |
| 56 TABLET'S | $109.88 | $1.96 | |
| 28 TABLET'S | $57.68 | $2.06 |
Januvia 100 MG Tablets are a prescription medication used in the treatment of type 2 diabetes mellitus. The active ingredient in Januvia is sitagliptin, which belongs to a class of medications known as dipeptidyl peptidase-4 (DPP-4) inhibitors. Januvia is designed to help regulate blood sugar levels in individuals with type 2 diabetes by influencing the activity of certain hormones involved in glucose control.
Inhibition of DPP-4:
Januvia exerts its effects by inhibiting the activity of dipeptidyl peptidase-4 (DPP-4), an enzyme present in various tissues, including the intestines and pancreas.
Incretin Hormones and Glucose Regulation:
In the digestive system, incretin hormones, particularly glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released in response to food intake.
Enhancement of Incretin Hormone Activity:
GLP-1 and GIP play crucial roles in glucose homeostasis. They stimulate insulin release from the pancreas and inhibit the release of glucagon, a hormone that raises blood sugar levels. Additionally, they slow down the absorption of glucose from the gut.
Prolonged Activity of Incretin Hormones:
DPP-4 is an enzyme that breaks down and inactivates incretin hormones, limiting their duration of action. By inhibiting DPP-4, Januvia helps prolong the activity of GLP-1 and GIP.
Increased Insulin Release and Reduced Glucagon Secretion:
With elevated levels of active incretin hormones, Januvia promotes increased insulin release from pancreatic beta cells. This insulin release is glucose-dependent, meaning it occurs in response to elevated blood sugar levels. Simultaneously, Januvia helps reduce the secretion of glucagon, which normally raises blood sugar levels.
Lowering Blood Sugar Levels:
The combined effects of increased insulin and reduced glucagon contribute to more effective glucose control. Januvia helps lower blood sugar levels, especially after meals when incretin hormones are most active.
Active Ingredient:
Sitagliptin (as Sitagliptin Phosphate Monohydrate): Januvia 100 MG Tablets contain sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor.
Dosage Information:
Strength: Each Januvia tablet is formulated to contain 100 milligrams of sitagliptin.
Dosage Regimen: The typical prescribed dosage is one Januvia 100 MG tablet taken orally once a day.
Administration: Januvia can be taken with or without food.
Individualized Dosage: Dosage adjustments may be made by healthcare professionals based on individual response, health conditions, and the overall treatment plan.
Here are key considerations regarding who can use Januvia:
Type 2 Diabetes Patients:
Januvia is specifically indicated for individuals diagnosed with type 2 diabetes mellitus.
Adults:
Januvia is intended for use in adults and is not typically prescribed for pediatric patients.
Individuals Requiring Blood Sugar Control:
Januvia is suitable for individuals whose blood sugar levels are not adequately controlled through lifestyle modifications such as diet and exercise alone.
Monotherapy or Combination Therapy:
Januvia can be used as a monotherapy, meaning it may be the only diabetes medication prescribed, or as part of combination therapy with other antidiabetic medications, depending on the individual's needs.
Those Without Hypersensitivity:
Individuals without a known hypersensitivity or allergy to sitagliptin (the active ingredient in Januvia) or any other components of the medication can safely use Januvia.
Renal Impairment Considerations:
Januvia dosage adjustments may be necessary for individuals with renal impairment. Healthcare providers will assess kidney function and determine the appropriate dosage.
Individualized Treatment Plans:
The decision to use Januvia is made by healthcare professionals based on an individual's health status, response to treatment, and overall diabetes management plan.
Pregnancy and Breastfeeding:
Pregnant or breastfeeding individuals should consult their healthcare provider before using Januvia, as the safety of the medication during pregnancy and lactation requires careful consideration.
Elderly Population:
Januvia can be prescribed for elderly individuals with type 2 diabetes. Dosage adjustments, if necessary, will be determined based on individual health conditions.
Here are some common mistakes to avoid:
Missed Doses:
Missing a dose of Januvia can impact blood sugar control. Adhere to the prescribed dosing schedule, and if a dose is missed, follow the guidance provided by your healthcare provider.
Doubling Up on Doses:
Do not double up on Januvia doses to compensate for a missed dose unless instructed to do so by your healthcare provider. Doubling doses can lead to unintended side effects.
Inconsistent Timing:
Take Januvia at the same time each day to maintain a consistent level of the medication in your system. Inconsistent timing may affect its effectiveness.
Not Following Lifestyle Modifications:
Januvia is most effective when used in conjunction with lifestyle modifications, such as dietary changes and regular exercise. Neglecting these aspects may compromise diabetes management.
Ignoring Symptoms or Side Effects:
Pay attention to any unusual symptoms or side effects and promptly report them to your healthcare provider. Ignoring potential issues may lead to complications.
Altering Dosages Without Consultation:
Do not adjust Januvia dosages on your own. Any changes should be made under the guidance of your healthcare provider based on careful consideration of your health status.
Failure to Communicate Changes:
Inform your healthcare provider of any changes in your health, including the development of new medical conditions or changes in other medications you are taking.
Not Monitoring Blood Sugar Levels:
Regularly monitor your blood sugar levels as directed by your healthcare provider. Failure to do so may result in inadequate diabetes management.
Ignoring Renal Function Considerations:
If you have renal impairment, follow your healthcare provider's recommendations regarding Januvia dosages. Ignoring these considerations can lead to complications.
Neglecting Regular Check-ups:
Regular check-ups with your healthcare provider are essential for assessing the ongoing effectiveness of Januvia and addressing any emerging concerns.
Pregnancy and Breastfeeding Concerns:
If you are pregnant, planning to become pregnant, or breastfeeding, discuss these considerations with your healthcare provider. Januvia use during pregnancy and lactation requires careful evaluation.
Not Seeking Medical Attention for Severe Side Effects:
Seek immediate medical attention if you experience severe allergic reactions or serious side effects, such as persistent stomach pain or pancreatitis symptoms.
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Q: What is Januvia 100 MG used for?
A: Januvia 100 MG Tablets are prescribed for the management of type 2 diabetes mellitus. The medication helps control blood sugar levels by enhancing insulin release and reducing glucagon secretion.
Q: How does Januvia work?
A: Januvia contains the active ingredient sitagliptin, which inhibits the enzyme dipeptidyl peptidase-4 (DPP-4). By inhibiting DPP-4, Januvia increases the levels of incretin hormones, promoting insulin release and suppressing glucagon secretion.
Q: What is the recommended dosage of Januvia 100 MG?
A: The typical dosage is one Januvia 100 MG tablet taken orally once a day. Dosage adjustments may be made by healthcare professionals based on individual response and health conditions.
Q: Can Januvia be used alone or with other medications?
A: Januvia can be used as a monotherapy or in combination with other antidiabetic medications, depending on the individual's needs and response to treatment.
Q: What should I do if I miss a dose of Januvia?
A: If you miss a dose, take it as soon as you remember. If it's almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses unless advised by your healthcare provider.
Q: Can Januvia cause low blood sugar (hypoglycemia)?
A: While Januvia itself may not typically cause hypoglycemia, when used with certain other diabetes medications, it can contribute to low blood sugar. Monitor blood sugar levels regularly and discuss any concerns with your healthcare provider.
Q: What are the common side effects of Januvia?
A: Common side effects include upper respiratory tract infections, headache, nasopharyngitis, and hypoglycemia. Serious but rare side effects may include pancreatitis and allergic reactions.
Q: Is Januvia safe for use during pregnancy and breastfeeding?
A: Pregnant or breastfeeding individuals should consult their healthcare provider before using Januvia, as the safety of the medication during pregnancy and lactation requires careful consideration.
Q: Can Januvia be used in individuals with kidney problems?
A: Dosage adjustments may be necessary for individuals with renal impairment. Healthcare providers will assess kidney function and determine the appropriate dosage.
Q: How should Januvia be stored?
A: Store Januvia at room temperature away from moisture and heat. Keep the medication in its original packaging, and do not use it after the expiration date.
Upper Respiratory Tract Infections:
Common symptoms may include a runny or stuffy nose, cough, and throat irritation.
Headache:
Mild to moderate headaches are a common side effect reported by some individuals using Januvia.
Nasopharyngitis (Inflammation of the Nasal Passages and Throat):
Symptoms may include a combination of nasal congestion, sneezing, and sore throat.
Hypoglycemia (Low Blood Sugar):
Januvia, when used in combination with certain other diabetes medications, may contribute to low blood sugar levels. Symptoms may include shakiness, sweating, irritability, and dizziness.
Pancreatitis:
While less common, pancreatitis has been reported as a side effect. Seek medical attention if you experience persistent severe abdominal pain.
Allergic Reactions:
Allergic reactions, though rare, may include skin rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you suspect an allergic reaction.
Joint Pain:
Some individuals may experience joint pain as a side effect of Januvia.
Increased Levels of Certain Liver Enzymes:
Januvia may lead to elevated levels of liver enzymes in some individuals. Regular monitoring during check-ups can help identify and manage this side effect.
Upper Abdominal Pain:
Mild to moderate upper abdominal pain has been reported by some individuals taking Januvia.
Urinary Tract Infections:
Symptoms may include pain or discomfort during urination, frequent urination, or lower abdominal pain.
Here are the primary uses of Januvia:
Blood Sugar Control:
Januvia is primarily employed to help control and regulate blood sugar levels in individuals diagnosed with type 2 diabetes.
Enhancing Insulin Release:
The medication works by enhancing the release of insulin from the pancreas. Insulin is a hormone crucial for transporting glucose from the bloodstream into cells, where it can be utilized for energy.
Reducing Glucagon Secretion:
Januvia helps reduce the secretion of glucagon, another hormone produced by the pancreas. Glucagon raises blood sugar levels by prompting the liver to release stored glucose. By inhibiting glucagon secretion, Januvia contributes to better blood sugar control.
Incretin Hormone Regulation:
Januvia exerts its effects by inhibiting dipeptidyl peptidase-4 (DPP-4), an enzyme that degrades incretin hormones. Incretin hormones, such as GLP-1 and GIP, play key roles in regulating insulin release and suppressing glucagon secretion.
Postprandial Glucose Control:
The medication is particularly effective in controlling postprandial (after-meal) glucose levels, assisting individuals in managing blood sugar spikes that commonly occur after eating.
Comprehensive Diabetes Management:
Januvia is often integrated into a comprehensive diabetes management plan that includes lifestyle modifications such as dietary changes and regular exercise.
Monotherapy or Combination Therapy:
Januvia may be used as a standalone medication (monotherapy) or in combination with other antidiabetic medications, depending on the individual's response and overall treatment plan.
Individualized Treatment Plans:
Treatment with Januvia is individualized, taking into account factors such as the patient's overall health, response to treatment, and the need for additional medications.
Here's a guide on how to use Januvia:
Prescription Compliance:
Take Januvia exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your healthcare professional.
Dosage and Timing:
The typical dosage of Januvia is one 100 MG tablet taken orally once a day.
Take the tablet with or without food, as directed by your healthcare provider.
It is advisable to take Januvia at the same time each day to maintain a consistent level of the medication in your body.
Oral Administration:
Januvia tablets are designed for oral administration. Swallow the tablet whole with a full glass of water.
Do not crush, break, or chew the tablet unless instructed to do so by your healthcare provider.
Missed Dose:
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
Do not double up on doses to make up for a missed dose unless advised by your healthcare provider.
Regular Monitoring:
Attend regular check-ups with your healthcare provider to monitor the effectiveness of Januvia in controlling your blood sugar levels.
Your healthcare provider may perform periodic blood tests to assess the medication's impact on your diabetes management.
Communicate Changes:
Inform your healthcare provider of any changes in your health status, medication adherence, or the occurrence of any side effects.
If there are concerns or difficulties in following the prescribed regimen, discuss them with your healthcare provider for guidance.
Renal Function Considerations:
If you have renal impairment, your healthcare provider may adjust the dosage based on your kidney function. Follow their recommendations closely.
Pregnancy and Breastfeeding:
If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The use of Januvia during pregnancy and lactation requires careful consideration.
Lifestyle Modifications:
Continue to follow any lifestyle modifications recommended by your healthcare provider, such as dietary changes and regular exercise, to complement the effects of Januvia.
The information provided on website is intended for educational purposes only and should not be used as a substitute for professional medical advice. Please consult a qualified healthcare professional for personalized medical advice.
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