Generic Name : Sitagliptin + Metformin HCL
Brand Name : Janumet
Manufacturer Name : Merck
Product Code : OBP 321
Delivery Days : 10 To 12 Working Days
Composition : Sitagliptin + Metformin Hcl.
Strength : 50+1000mg
Packaging : Tablet (Blisters)
Presentation : Pills Strip
Drug Class : Dipeptidyl peptidase-4 (DPP-4) inhibitors +biguanides
Prescribed For : Adult patients with type 2 diabetes mellitus
Side Effects : Nausea, vomiting, stomach upset, diarrhea, headache, weakness, or a metallic taste in the mouth
| Pack Size/Qty | Price | Price Per Pill or unit | |
| 90 TABLET'S | $94.50 | $1.05 | |
| 60 TABLET'S | $69.00 | $1.15 | |
| 30 TABLET'S | $34.80 | $1.16 |
Janumet 50/1000 MG Tablets is a prescription medication used for the management of type 2 diabetes mellitus. It is a combination drug that contains two active ingredients: sitagliptin and metformin. Each of these components works in different ways to help control blood sugar levels.
Here's an explanation of how each component functions:
Sitagliptin:
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. DPP-4 is an enzyme that breaks down incretin hormones, specifically glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). GLP-1 and GIP play crucial roles in glucose regulation:
GLP-1: Stimulates insulin release from the pancreas in response to food intake. It also inhibits the release of glucagon, a hormone that increases blood sugar levels.
GIP: Stimulates insulin release and helps control blood sugar after meals.
By inhibiting DPP-4, sitagliptin increases the levels of GLP-1 and GIP, leading to enhanced insulin release and reduced glucagon secretion. This results in improved blood sugar control.
Metformin:
Metformin is a biguanide that primarily works by improving insulin sensitivity and reducing the production of glucose in the liver. It exerts its effects through the following mechanisms:
Decreased Glucose Production: Metformin inhibits the liver's ability to produce glucose, reducing the amount of sugar released into the bloodstream.
Increased Insulin Sensitivity: It enhances the sensitivity of peripheral tissues, such as muscles, to insulin. This allows cells to take up more glucose from the bloodstream.
Together, these actions of metformin contribute to lower fasting and postprandial (after-meal) blood sugar levels.
Combination Benefits:
Comprehensive Approach: The combination of sitagliptin and metformin provides a more comprehensive approach to diabetes management by addressing different aspects of glucose regulation.
Lowering Blood Sugar Levels: By enhancing insulin release, reducing glucagon secretion, and improving insulin sensitivity, Janumet helps lower and regulate blood sugar levels in individuals with type 2 diabetes.
Active Ingredients:
Sitagliptin (50 MG): Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of incretin hormones, such as GLP-1 and GIP, leading to enhanced insulin release and reduced glucagon secretion.
Metformin (1000 MG): Metformin is a biguanide that improves insulin sensitivity and reduces the production of glucose in the liver. It also enhances the uptake of glucose by peripheral tissues.
2. Dosage Information:
The dosage of Janumet 50/1000 MG Tablets is typically individualized based on the patient's response to treatment and specific healthcare provider recommendations.
The usual recommended dose involves taking one tablet orally twice daily with meals to optimize absorption and minimize gastrointestinal side effects associated with metformin.
Healthcare providers may adjust the dosage based on factors such as renal function, blood sugar levels, and overall response to the medication.
Janumet 50/1000 MG Tablets are prescribed for individuals with type 2 diabetes mellitus as part of their comprehensive treatment plan. It is suitable for those who meet specific criteria and may be recommended by healthcare providers under various circumstances:
Type 2 Diabetes Diagnosis:
Janumet 50/1000 MG is intended for individuals diagnosed with type 2 diabetes, especially when blood sugar levels are not adequately controlled by metformin alone.
Adult Patients:
This medication is generally recommended for adults, and its safety and effectiveness in pediatric populations are not well-established.
Inadequate Glycemic Control with Metformin Alone:
Janumet is often prescribed when metformin alone does not provide sufficient control over blood sugar levels. The addition of sitagliptin complements the action of metformin for better glycemic control.
Individuals with Stable Renal Function:
Healthcare providers consider the patient's renal (kidney) function when prescribing Janumet. Dosage adjustments may be necessary in individuals with impaired renal function.
Doctor's Assessment and Prescription:
The decision to use Janumet 50/1000 MG Tablets is made by healthcare providers based on a thorough assessment of the patient's overall health, medical history, and response to treatment.
Here are some key mistakes to avoid:
Skipping Doses:
Skipping doses of Janumet can disrupt the medication's consistent action in controlling blood sugar levels. Take the prescribed dosage regularly and as directed by your healthcare provider.
Inconsistent Timing:
Establish a consistent schedule for taking Janumet. Inconsistent timing may lead to fluctuations in blood levels of the medication, affecting its overall effectiveness.
Not Taking with Meals:
Janumet is usually recommended to be taken with meals. Taking it on an empty stomach may increase the risk of gastrointestinal side effects associated with metformin. Follow the prescribed instructions regarding mealtime administration.
Crushing or Chewing Tablets:
Janumet tablets should be swallowed whole with a glass of water. Avoid crushing or chewing the tablets, as this may affect the controlled release mechanism and absorption of the medication.
Not Monitoring Blood Sugar Levels:
Regularly monitor your blood sugar levels as advised by your healthcare provider. Failure to monitor may result in a lack of information on the medication's effectiveness and potential adjustments needed in the treatment plan.
Not Reporting Side Effects:
If you experience any side effects, such as gastrointestinal discomfort, allergic reactions, or changes in health, promptly report them to your healthcare provider. Ignoring or not reporting side effects can hinder proper management.
Not Following Lifestyle Modifications:
Janumet is part of a comprehensive diabetes management plan. Neglecting lifestyle modifications, including a healthy diet and regular exercise, may limit the overall effectiveness of the treatment.
Self-Adjusting Dosages:
Do not adjust the dosage of Janumet without consulting your healthcare provider. Dosage adjustments should be made under professional guidance based on your individual response and health status.
Not Consulting Before Pregnancy:
If you are planning to become pregnant or are pregnant, consult with your healthcare provider. Janumet's use during pregnancy requires careful consideration, and alternative treatments may be recommended.
Ignoring Regular Check-ups:
Attend regular check-ups with your healthcare provider. These appointments are crucial for assessing your overall health, glycemic control, and making any necessary adjustments to your diabetes management plan.
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Q: What is Janumet 50/1000 MG used for?
A: Janumet 50/1000 MG Tablets are prescribed for individuals with type 2 diabetes to help manage and control blood sugar levels. It combines sitagliptin and metformin to enhance insulin release, reduce glucagon secretion, and improve insulin sensitivity.
Q: How should I take Janumet 50/1000 MG Tablets?
A: Take Janumet as prescribed by your healthcare provider. Typically, one tablet is taken orally twice daily with meals. Swallow the tablet whole with a glass of water and do not crush or chew it.
Q: Can I adjust the dosage on my own?
A: No, do not adjust the dosage without consulting your healthcare provider. Dosage adjustments should only be made under professional guidance based on your individual response to the medication.
Q: Are there any lifestyle changes I should make while taking Janumet?
A: Yes, Janumet is part of a comprehensive diabetes management plan. Adopting a healthy diet, engaging in regular exercise, and maintaining a consistent meal schedule are essential components of managing type 2 diabetes.
Q: What should I do if I miss a dose of Janumet?
A: If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses.
Q: Can Janumet cause hypoglycemia (low blood sugar)?
A: Yes, hypoglycemia is a potential side effect of Janumet. Maintain regular meal schedules, monitor blood sugar levels, and follow your healthcare provider's recommendations for managing low blood sugar.
Q: What are the common side effects of Janumet 50/1000 MG Tablets?
A: Common side effects may include gastrointestinal discomfort, headache, upper respiratory tract infections, joint pain, and hypertension. However, not everyone experiences these side effects.
Q: Can Janumet be used during pregnancy?
A: Pregnant or breastfeeding individuals should consult their healthcare provider before using Janumet. The safety of the medication during pregnancy requires careful consideration, and alternative treatments may be recommended.
Q: How often should I have check-ups while taking Janumet?
A: Attend regular check-ups with your healthcare provider. These appointments are crucial for assessing your overall health, monitoring blood sugar levels, and making any necessary adjustments to your diabetes management plan.
Q: Can I drink alcohol while taking Janumet?
A: Consult your healthcare provider regarding alcohol consumption while taking Janumet. Alcohol can affect blood sugar levels and may interact with the medication.
some common ones include:
Gastrointestinal Discomfort:
Description: Upset stomach, nausea, vomiting, diarrhea, or abdominal discomfort.
Management: Taking Janumet with meals can help reduce gastrointestinal side effects. If symptoms persist or are severe, consult your healthcare provider.
Hypoglycemia (Low Blood Sugar):
Description: Symptoms may include shakiness, sweating, headache, dizziness, irritability, or confusion.
Management: Maintain regular meal schedules, monitor blood sugar levels, and follow your healthcare provider's recommendations for managing hypoglycemia.
Upper Respiratory Tract Infections:
Description: Common cold symptoms such as nasal congestion, sore throat, or cough.
Management: These symptoms are usually mild. If they persist or worsen, consult your healthcare provider.
Headache:
Description: Mild to moderate headaches.
Management: Adequate hydration and rest may help alleviate headaches. If persistent, inform your healthcare provider.
Joint Pain:
Description: Pain or discomfort in the joints.
Management: If joint pain is bothersome, consult your healthcare provider for guidance.
Hypertension (High Blood Pressure):
Description: Elevation in blood pressure levels.
Management: Regular monitoring of blood pressure and adherence to lifestyle modifications may be recommended.
Hypersensitivity Reactions:
Description: Allergic reactions such as rash, itching, or swelling.
Management: Seek immediate medical attention if you experience signs of an allergic reaction. Discontinue Janumet and consult your healthcare provider.
Renal Function Changes:
Description: Changes in kidney function, including elevated creatinine levels.
Management: Regular monitoring of renal function is essential. Inform your healthcare provider if you have pre-existing kidney conditions.
Vitamin B12 Deficiency:
Description: Long-term use may lead to decreased vitamin B12 levels.
Management: Regular monitoring of vitamin B12 levels and supplementation if necessary.
Increased Risk of Pancreatitis:
Description: In rare cases, an increased risk of pancreatitis (inflammation of the pancreas).
Management: Report severe abdominal pain, persistent nausea, or vomiting to your healthcare provider immediately.
Here are the primary uses of Janumet 50/1000 MG Tablets:
Glycemic Control:
Janumet is used to achieve and maintain optimal glycemic control in individuals with type 2 diabetes. It helps regulate blood sugar levels throughout the day, including fasting and postprandial (after-meal) periods.
Adjunct to Diet and Exercise:
Janumet is typically prescribed as an adjunct to diet and exercise in individuals whose blood sugar levels are not adequately controlled by metformin alone. Lifestyle modifications, including healthy eating and regular physical activity, are essential components of diabetes management.
Comprehensive Approach:
The combination of sitagliptin and metformin in Janumet addresses different mechanisms involved in glucose regulation. Sitagliptin enhances insulin release and reduces glucagon secretion, while metformin improves insulin sensitivity and reduces glucose production in the liver.
Reducing HbA1c Levels:
Janumet aims to reduce glycosylated hemoglobin (HbA1c) levels, which provide a measure of average blood sugar levels over a few months. Lowering HbA1c reflects improved long-term glycemic control.
Individualized Treatment:
The use of Janumet is individualized, with healthcare providers determining the appropriate dosage based on factors such as the patient's response to treatment, renal function, and overall health.
Here's a general guide on how to use Janumet:
Dosage and Timing:
Take Janumet 50/1000 MG Tablets as prescribed by your healthcare provider. The typical dosage involves taking one tablet orally twice daily.
It is recommended to take the medication with meals to optimize absorption and reduce the risk of gastrointestinal side effects associated with metformin.
Swallow Whole:
Swallow the tablet whole with a glass of water. Do not crush, break, or chew the tablet, as it may affect the release mechanism and absorption of the medication.
Consistent Timing:
Establish a consistent schedule for taking Janumet. This helps maintain steady blood levels of the medication, contributing to its effectiveness in controlling blood sugar throughout the day.
Follow Healthcare Provider Instructions:
Always follow the specific instructions provided by your healthcare provider. Dosage may be adjusted based on individual response, renal function, and other health considerations.
Regular Monitoring:
Regularly monitor your blood sugar levels as directed by your healthcare provider. This helps assess the medication's effectiveness and allows for any necessary adjustments to the treatment plan.
Do Not Skip Doses:
Take Janumet regularly and do not skip doses. If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses.
Report Side Effects:
If you experience any unusual or severe side effects, such as allergic reactions or gastrointestinal issues, contact your healthcare provider promptly.
Attend Regular Check-ups:
Attend scheduled check-ups with your healthcare provider to assess your overall health, glycemic control, and potential adjustments to your diabetes management plan.
Lifestyle Modifications:
Complement the use of Janumet with lifestyle modifications, including a healthy diet and regular physical activity. Collaborate with healthcare professionals to optimize your overall diabetes management.
The information provided on website is intended for educational purposes only and should not be used as a substitute for professional medical advice. Please consult a qualified healthcare professional for personalized medical advice.
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